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![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Photoredox-Catalyzed Decarboxylative Elimination via Halogen Atom Transfer
Deshkanwar Singh Brar1, Roberto Aponte1, Jon Tunge1
1Department of Chemistry, The University of Kansas, 1567 Irving Rd., Lawrence, Kansas 66045, United States.
Abstract:
Enamides and enecarbamates offer an excellent balance between stability and reactivity. Decarboxylation of widely available amino acids offers a green and efficient alternative to accessing these reagents. The present study describes a photocatalytic approach for the direct decarboxylative synthesis of enamides via sequential radical decarboxylation and putative halogen-atom transfer (XAT). This operationally simple, economical protocol is scalable and allows for mild reaction conditions and short reaction times. In addition, it obviates the need for transition metals and preactivation of carboxylic acids.
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