Related Experiment Video

Updated: May 15, 2025

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

2.6K

Gut microbiota dysbiosis in infantile cholestatic hepatopathy

Yi Zou1, Wenhao Ni2, Yong Zhou2,3

  • 1Department of Clinical Laboratory, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China.

Frontiers in Pediatrics
|April 8, 2025
PubMed

Insights

Gut microbiota dysbiosis is linked to infantile cholestatic hepatopathy (ICH). The study found increased Streptococcus in infants with ICH, suggesting its potential as a biomarker for identifying this condition.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Pediatric Hepatology

Background:

  • Infantile cholestatic hepatopathy (ICH) is a prevalent condition in infants.
  • The gut microbiota's role in liver and gallbladder diseases is recognized, but its specific connection to ICH is not well understood.

Purpose of the Study:

  • To investigate the relationship between gut microbiota composition and infantile cholestatic hepatopathy (ICH).
  • To identify potential microbial biomarkers for diagnosing ICH in infants.

Main Methods:

  • Stool samples were collected from 33 infants with ICH (age ≤3 months) and 19 healthy controls.
  • Intestinal microbiota was analyzed using 16S rDNA sequencing.
  • Differences in microbiota structure, function, and specific taxa between groups were assessed.

Main Results:

  • Alpha-diversity indexes (Chao1, ACE) were significantly higher in the ICH group.
  • Enrichment of bacteria taxa, including Streptococcus, was observed in the ICH group.
  • Streptococcus showed high value in distinguishing ICH from healthy controls via ROC analysis; 59 metabolic pathways were potentially associated with ICH.

Conclusions:

  • Gut microbiota dysbiosis is associated with infantile cholestatic hepatopathy.
  • Streptococcus can serve as a valuable biomarker for identifying ICH in infants.
Abstract

Keywords:
16S rDNAStreptococcusbiomarkerinfantile cholestatic hepatopathyintestinal microbiota

More Related Videos

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model06:51

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

1.1K
Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates06:10

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

1.8K

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
70.8K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
336
What is Monogastric Digestion?01:50

What is Monogastric Digestion?

The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
69.8K
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
363