Related Experiment Video
Updated: May 15, 2025
A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Published on: February 7, 2015
Quantitative correlation between carotid or lower limb atherosclerosis and coronary heart disease: a retrospective
Zeyu Jiang1, Shimiao Ruan2, Kun Zhao3
1Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Insights
Vascular ultrasound scores of carotid and lower limb atherosclerosis can predict the need for coronary revascularization. This establishes a predictive model for coronary artery disease (CAD) using peripheral vascular disease assessment.
Area of Science:
- Cardiovascular Medicine
- Diagnostic Imaging
- Vascular Surgery
Background:
- Early diagnosis and intervention are crucial for managing coronary heart disease (CHD).
- Ultrasound is utilized for risk stratification in patients with coronary artery disease.
- Limited research quantifies the link between atherosclerosis in carotid or lower limb vessels and the need for coronary revascularization.
Purpose of the Study:
- To demonstrate that semi-quantitative atherosclerosis assessment in neck or lower extremity vessels predicts the requirement for coronary revascularization.
- To establish a predictive model for coronary revascularization based on peripheral vascular disease.
Main Methods:
- Semi-quantitative analysis of coronary artery and peripheral vascular stenosis was performed.
- Data were collected from 306 patients who underwent coronary angiography and peripheral vascular ultrasound.
Main Results:
- Vascular ultrasound scores (semi-quantitative, grade, and lower limb) positively correlated with the Gensini score for coronary artery lesions.
- The semi-quantitative score (score=2) showed 83.74% sensitivity and 61.72% specificity for predicting coronary revascularization.
- The lower extremity score (score=3) demonstrated 90.24% sensitivity and 54.55% specificity for predicting coronary revascularization.
Conclusions:
- Carotid and lower limb vascular ultrasound scores are predictive factors for coronary revascularization.
- These scores can serve as auxiliary tools for the early diagnosis of coronary artery disease.
Background:
Early diagnosis and intervention are key for the treatment of coronary heart disease (CHD). Ultrasound is used to assess risk stratification in patients with coronary artery disease. However, few studies quantify the relationship between carotid or lower limb atherosclerosis and coronary revascularization. The purpose of this study is to demonstrate that the semi-quantitative degree of atherosclerosis in the neck or lower extremity vessels can predict the need for coronary revascularization, thereby establishing a predictive model for coronary revascularization based on peripheral vascular disease.
Methods:
Patients who underwent coronary angiography and peripheral vascular ultrasound were randomly selected for semi-quantitative analysis of the degree of coronary artery and peripheral vascular stenosis. Data from 306 patients were collected.
Results:
The semiquantitative score, grade score and lower limb score from vascular ultrasound were positively correlated with the Gensini score of coronary artery lesions. The semi-quantitative score (score = 2) predicted the sensitivity and specificity for coronary revascularization at 83.74% and 61.72%, respectively. The graded score (score = 2) predicted the sensitivity and specificity for coronary revascularization at 77.24% and 72.13%, respectively. The lower extremity score (score = 3) predicted the sensitivity and specificity for coronary revascularization at 90.24% and 54.55%, respectively.
Conclusions:
Carotid semiquantitative scores, grade scores, and lower limb scores are predictive factors for the need for coronary revascularization and can serve as auxiliary examinations for the early diagnosis of coronary artery disease.
More Related Videos
11:00A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
Published on: June 22, 2010
06:04Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
Related Concept Videos
01:11Observational Studies
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
02:20Correlations