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Assessment of Quality of Life and Behavioral Problems in Children with Central Precocious Puberty

Shaymaa Raafat1, Esraa Abdelaal1, Ihsan Mowafi1

  • 1Pediatric Endocrinology and Diabetes Unit, Pediatric Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Oman Medical Journal
|April 8, 2025
PubMed

Insights

Central precocious puberty (CPP) negatively impacts children's quality of life (QoL), but not behavior or cognition. Treatment with gonadotropin-releasing hormone (GnRH) analogues improved QoL and behavior scores.

Area of Science:

  • Pediatric Endocrinology
  • Child Psychology
  • Quality of Life Research

Background:

  • Central precocious puberty (CPP) is a condition where puberty begins unusually early.
  • CPP can have significant psychosocial implications for affected children.
  • Understanding the impact of CPP on quality of life (QoL) and behavior is crucial for effective management.

Purpose of the Study:

  • To evaluate the psychosocial impact of CPP on children.
  • To assess changes in psychosocial aspects after treatment with gonadotropin-releasing hormone (GnRH) analogues.

Main Methods:

  • A case-control study compared 30 children with CPP to 30 controls.
  • Assessments included anthropometric measurements, hormonal profiles, and neuropsychological testing (QoL, CBCL, IQ).

Main Results:

  • CPP children exhibited significantly lower health-related QoL scores compared to controls, excluding school functioning.
  • No significant differences were observed in Child Behavior Checklist (CBCL) scores or cognitive function between groups.
  • One year of GnRH analogue treatment led to significant improvements in QoL and CBCL T-scores.

Conclusions:

  • CPP is associated with notable QoL impairments but does not significantly affect behavior or cognition.
  • GnRH analogue therapy demonstrates efficacy in improving QoL and behavioral scores in children with CPP.
Abstract

Keywords:
ChildGonadotropinsPuberty, PrecociousQuality of Life

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