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Updated: May 15, 2025
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Cardiovascular disease in chronic kidney disease
Katharina Marx-Schütt1, David Z I Cherney2, Joachim Jankowski3
1Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen, Pauwelsstraße 30, Aachen D-52074, Aachen, Germany.
Insights
Chronic kidney disease (CKD) significantly increases cardiovascular disease (CVD) risk. Understanding the link between CKD and CVD is vital for better patient outcomes and treatment strategies.
Area of Science:
- Nephrology and Cardiology
- Cardiovascular Medicine
- Renal Disease Research
Background:
- Chronic kidney disease (CKD) is a significant risk factor for cardiovascular disease (CVD), including coronary artery disease, stroke, heart failure, arrhythmias, and sudden cardiac death.
- The co-existence of CKD and CVD adversely impacts patient prognosis, highlighting a complex interplay between these conditions.
Purpose of the Study:
- To review the current understanding of the pathophysiological mechanisms linking CKD and CVD.
- To discuss the clinical implications and treatment challenges for patients with both CKD and CVD.
Main Methods:
- This is a State-of-the-Art Review.
- The review synthesizes current knowledge on the relationship between CKD and CVD.
Main Results:
- Shared risk factors like diabetes and hypertension contribute to both CKD and CVD.
- Pathophysiological mechanisms include inflammation, anemia, volume overload, and uremic toxins.
- Early identification and characterization of CKD are essential for accurate CVD risk prediction.
Conclusions:
- Effective management of CVD risk in CKD patients requires a multidisciplinary approach involving nephrologists and cardiologists.
- Addressing the complex pathophysiological links is crucial for improving patient outcomes.
Abstract:
Individuals with chronic kidney disease (CKD) exhibit an increased risk for the development of cardiovascular disease (CVD) with its manifestations coronary artery disease, stroke, heart failure, arrhythmias, and sudden cardiac death. The presence of both, CVD and CKD has a major impact on the prognosis of patients. This association likely reflects the involvement of several pathophysiological mechanisms, including shared risk factors (e.g. diabetes and hypertension), as well as other factors such as inflammation, anaemia, volume overload, and the presence of uraemic toxins. Identifying and characterizing CKD is crucial for appropriate CVD risk prediction. Mitigating CVD risk in patients with CKD mandates a multidisciplinary approach involving cardiologists, nephrologists, and other health care professionals. The present State-of-the-Art Review addresses the current understanding on the pathophysiological link between CVD and CKD, clinical implications and challenges in the treatment of these patients.
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