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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Updated: May 15, 2025

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Optimizing Transdermal Drug Delivery with Novasome Nanocarriers: A Quality by Design (QbD) Framework.

Prabhjot Kaur1, Priyanka Kriplani1

  • 1Department of Pharmaceutics, Guru Gobind Singh College of Pharmacy, Yamuna Nagar 135001, Haryana, India.

Current Drug Delivery
|April 8, 2025
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Summary

Novasome technology, a novel drug delivery system, offers superior effectiveness and efficiency over traditional liposomes. This advanced encapsulation method utilizes free fatty acids, cholesterol, and surfactants for enhanced medication administration.

Keywords:
Novasomesconventional liposomes.quality by designtransdermal deliveryvesicular system

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Conventional liposome systems face limitations in drug delivery effectiveness and efficiency.
  • Novasome technology presents a revolutionary encapsulation-based alternative.
  • The core components of novasomes include free fatty acid, cholesterol, and surfactant, contributing to improved vesicle properties.

Purpose of the Study:

  • To explore the optimization of novasome formulations for enhanced drug delivery.
  • To investigate the impact of component ratios and manufacturing processes on vesicle properties.
  • To highlight the application of Quality by Design (QBD) and Design of Experiments (DoE) in developing effective novasomal formulations.

Main Methods:

  • Review of existing research on novasome formulation components and their impact on vesicle characteristics.
  • Application of Quality by Design (QBD) principles.
  • Utilization of Design of Experiments (DoE) for optimizing formulation and process parameters.
  • Analysis of factors influencing drug loading and nano-metric form.

Main Results:

  • Novasome technology demonstrates superior effectiveness and efficiency compared to conventional liposomes.
  • Various drugs, including vaccines, niflumic acid, zolmitriptan, and terconazole, have been successfully delivered using novasomes.
  • Optimal ratios of core components and critical manufacturing determinants are crucial for achieving desired drug loading and nano-metric form.

Conclusions:

  • Novasome technology offers a promising platform for advanced drug delivery.
  • The strategic application of QBD and DoE is essential for developing robust and efficient novasomal formulations.
  • Further research into optimizing novasome formulations can lead to significant advancements in medication administration.