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Invasiveness of Aeromonas spp. in relation to biotype, virulence factors, and clinical features
Abstract:
Of 69 fecal isolates of Aeromonas spp., 18 had the ability to invade HEp-2 cells. Invasiveness correlated with biotype; of the 18 invasive strains, 16 were A. sobria and 2 were A. hydrophila. No invasive strains were found among the A. caviae. Of the 18 invasive strains, 13 were enterotoxigenic. Of the enterotoxigenic and invasive strains, 12 were A. sobria, but enterotoxicity was also more common among noninvasive strains of A. sobria. Fucose-resistant hemagglutination was also more common in A. sobria, but invasive strains were equally divided between fucose-resistant hemagglutination and other patterns. Detailed clinical information was available for 27 of the 69 strains. All 15 strains of A. sobria or A. hydrophila associated with diarrhea were enterotoxigenic; 6 of the 10 strains of A. sobria were also invasive. Blood was present in the stool samples of five of the six patients with invasive A. sobria and in none of the patients with noninvasive strains. Although limited, these observations suggest that dysenteric symptoms may be produced by invasive Aeromonas spp.
Insights
Invasive Aeromonas strains, particularly Aeromonas sobria, were linked to diarrhea and dysenteric symptoms. Invasiveness and enterotoxicity were common in Aeromonas sobria associated with bloody stools.
Area of Science:
- Microbiology
- Infectious Diseases
Background:
- Aeromonas species are increasingly recognized as human pathogens.
- Understanding the virulence factors of Aeromonas is crucial for diagnosing and treating infections.
Purpose of the Study:
- To investigate the relationship between Aeromonas species invasiveness, enterotoxicity, and clinical manifestations.
- To determine which Aeromonas biotypes are associated with invasive and enterotoxigenic properties.
Main Methods:
- Fecal isolates of Aeromonas spp. were tested for HEp-2 cell invasiveness and enterotoxicity.
- Biotype and hemagglutination patterns were analyzed.
- Clinical data, including stool characteristics, were correlated with isolate properties.
Main Results:
- Eighteen of 69 Aeromonas isolates were invasive, predominantly Aeromonas sobria (16 strains).
- Invasive strains were frequently enterotoxigenic (13/18).
- Invasive Aeromonas sobria isolates were associated with bloody diarrhea in patients.
Conclusions:
- Invasiveness is a significant characteristic of certain Aeromonas strains, particularly Aeromonas sobria.
- Invasive Aeromonas spp. may play a role in causing dysenteric symptoms.
- Further research is needed to elucidate the full spectrum of Aeromonas-associated diseases.