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Related Concept Videos

Ultrasonography01:17

Ultrasonography

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Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
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Related Experiment Video

Updated: May 15, 2025

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
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Quantitative Dynamic Contrast-Enhanced Ultrasound Confirms Renal Obstruction: A Feasibility Study.

Kourosh Kalayeh1,2, Sapan N Ambani2, Man Zhang1

  • 1Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|April 8, 2025
PubMed
Summary

Dynamic contrast-enhanced ultrasound (DCEUS) shows promise for diagnosing ureteropelvic junction obstruction (UPJO). DCEUS mean-transit time (MTT) effectively differentiates obstructed from normal kidneys, potentially reducing the need for radiation-based imaging.

Keywords:
contrast mediadynamic contrast‐enhanced ultrasoundhydronephrosisnuclear medicine diuretic renographyureteropelvic junction obstruction

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Area of Science:

  • Medical Imaging
  • Urology
  • Nephrology

Background:

  • Ureteropelvic junction obstruction (UPJO) is a common cause of hydronephrosis in children and adults.
  • Accurate diagnosis of UPJO is crucial for timely intervention and preservation of renal function.
  • Current diagnostic modalities, such as nuclear medicine (NM) scans, involve ionizing radiation.

Purpose of the Study:

  • To evaluate the potential of dynamic contrast-enhanced ultrasound (DCEUS) in diagnosing UPJO.
  • To determine if DCEUS can identify differences in renal parenchymal microcirculation between normal and obstructed kidneys.
  • To compare DCEUS parameters with established nuclear medicine (NM) diuretic half-time (T1/2) measurements.

Main Methods:

  • Prospective study of 8 subjects (16 kidneys) with unilateral UPJO requiring surgery.
  • Pre- and post-surgery DCEUS and NM imaging were performed.
  • DCEUS-derived time-intensity curves were analyzed for mean-transit time (MTT), time-to-peak (TTP), and full-width at half-maximum (FWHM).
  • Statistical analysis included paired and unpaired Student t-tests and point-biserial correlation.

Main Results:

  • Pre-operative DCEUS mean-transit time (MTT) was significantly longer in obstructed kidneys compared to normal kidneys (p < 0.001).
  • Post-operative MTT normalized after pyeloplasty (p < 0.001).
  • DCEUS MTT demonstrated high accuracy (ROC AUC = 0.97) in categorizing kidneys based on NM drainage time, correlating well with NM T1/2 (r = -0.78, p < 0.001).

Conclusions:

  • DCEUS MTT is a promising, non-invasive tool for assessing UPJO.
  • DCEUS may serve as a standalone or complementary diagnostic modality to NM, avoiding ionizing radiation.
  • Further research with larger cohorts and diverse patient groups is needed to confirm clinical utility.