Related Experiment Video
Updated: May 15, 2025
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
Posterior Hyaloid Adhesion as an Optical Coherence Tomography Biomarker of Active Toxoplasma Retinochoroiditis
Kiran Chandra1, Rajeev Reddy Pappuru1, Shabtab Nasir2
1Anant Bajaj Retina Institute, LV Prasad Eye Institute, Hyderabad, India.
Purpose:
To explore the utility of Posterior Hyaloid Adhesions (PHA) as an Optical Coherence Tomography (OCT) biomarker of toxoplasma retinochoroiditi.
Methods:
A retrospective review of OCT scans of infective retinitis cases to evaluate the presence of PHA at the time of presentation.
Results:
Ninety-seven eyes of active toxoplasma retinochoroiditis and 125 eyes of retinitis of other etiologies were included. OCT feature of PHA was present in 70 eyes (72%) in the toxoplasmosis group as compared to other retinitis where it was present in 32 eyes (26%). Univariate analysis revealed that PHA was significantly more prevalent in toxoplasma retinochoroiditis compared to other retinitis. Multivariate analysis, adjusted for age and sex, revealed an odds ratio of finding PHA was 5.22 in patients with toxoplasma retinochoroiditis as compared to other retinitis. (p < 0.001).
Conclusion:
PHA to a retinitis lesion can serve as a diagnostic OCT biomarker for active toxoplasma retinochoroiditis.
