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Related Experiment Video

Updated: Jun 14, 2025

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
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Pelvic Lymph Node Dissection in Prostate Cancer: Evidence and Implications.

Matthew J Roberts1, Giorgio Gandaglia2, Daniela E Oprea-Lager3

  • 1Department of Urology, Royal Brisbane and Women's Hospital, Brisbane, Australia; UQ Centre for Clinical Research, University of Queensland, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, Australia.

European Urology
|April 8, 2025
PubMed
Summary

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Articles linked to this work by shared authors, journal, and citation graph.

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Beyond Prostate-Specific Antigen and Conventional Imaging: How Prostate-Specific Membrane Antigen Positron Emission Tomography Is Transforming Postradiation Therapy Monitoring in Oligometastatic Prostate Cancer.

International journal of radiation oncology, biology, physics·2026
Same authorSame journal

EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer-2026 Update. Part I: Screening, Diagnosis, and Local Treatment with Curative Intent.

European urology·2026
Same authorSame journal

EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer. Part II-2026 Update: Treatment of Relapsing and Metastatic Prostate Cancer.

European urology·2026
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The value of target-site physiologically-based pharmacokinetics for high-affinity small molecules: a mechanistic foundation for precision dosing in oncology and hematology.

Cancer chemotherapy and pharmacology·2026
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Diagnosis and Staging of Patients with Prostate Cancer: Report from the 2025 Advanced Prostate Cancer Consensus Conference (APCCC) Diagnostics.

European urology·2026
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Terbium-161 might be superior to lutetium-177 for oligometastases - Authors' reply.

The Lancet. Oncology·2026

Extended pelvic lymph-node dissection (ePLND) for prostate cancer is under review due to new imaging techniques. Predicting benefit remains challenging, requiring patient counseling on uncertainty and risks.

Area of Science:

  • Urology
  • Oncology
  • Medical Imaging

Background:

  • The utility of extended pelvic lymph-node dissection (ePLND) in prostate cancer management is being re-evaluated.
  • Advances in prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) offer new staging possibilities.

Discussion:

  • Predicting patient eligibility for ePLND based on current evidence is difficult.
  • The potential benefits of ePLND must be weighed against its associated morbidity.

Key Insights:

  • Current imaging modalities complicate the selection of patients who would benefit from ePLND.
  • Shared decision-making is crucial, involving thorough patient counseling regarding the uncertainties and risks of ePLND.

Outlook:

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  • Further research is needed to refine patient selection criteria for ePLND.
  • Integrating advanced imaging with clinical factors may improve treatment personalization for prostate cancer.