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Subcortical Brain Regions Associated With Seizure Risk in Patients With IDH Mutated Diffuse Gliomas
Ann Westermark1, Markus Fahlström2, Sadia Mirza3
1Department of Medical Sciences, Neurology, Uppsala University, Uppsala, Sweden.
Brain and Behavior
|April 9, 2025
Summary
Tumor location in the brain influences seizure risk in diffuse glioma patients. Specific left hemisphere regions showed decreased or increased seizure likelihood, impacting treatment strategies for brain tumor-related epilepsy.
Area of Science:
- Neuro-oncology
- Epileptology
- Radiology
Background:
- Seizures affect 60-90% of diffuse glioma patients.
- Understanding seizure association with tumor location is crucial.
Purpose of the Study:
- Investigate the link between diffuse glioma location (cortical, subcortical, white matter) and seizures.
- Identify specific brain regions associated with increased or decreased seizure risk.
Main Methods:
- Retrospective analysis of 93 adult diffuse glioma patients (2005-2021).
- MRI-based tumor segmentation and spatial normalization (MNI).
- Examined relationship between voxel location, white matter involvement, and preoperative seizures.
Main Results:
- 75% of patients experienced seizures.
- Decreased seizure risk in left fronto-mesial/dorsal voxels (A3C1S1).
- Increased seizure risk in left supramarginal/posterior insular voxels (A4C2S3).
- Differences in seizure risk noted between oligodendrogliomas and astrocytomas.
Conclusions:
- Diffuse glioma location significantly impacts epileptogenicity.
- Cortical and subcortical tumor localization are key factors.
- Findings support personalized treatment and further research into brain tumor-related epilepsy (BTRE).
Related Concept Videos
01:13Seizures: Classification
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
01:20Seizures l: Introduction
Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...