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Published on: September 16, 2017
Association Between Ankle-Brachial Index and Risk of Early Neurological Deterioration After Acute Isolated Pontine
Dong-Bo Liu1, Bing-Xian Zhang1, Yao Zhou1
1Department of Neurology, Henan Provincial People's Hospital (People's Hospital of Zhengzhou University), Henan Provincial People's Hospital (Zhengzhou University People's Hospital), No.7 Weiwu Road, Zhengzhou, Henan Province, China.
Low ankle-brachial index (ABI) increases early neurological deterioration risk after pontine infarction. Borderline ABI may reduce this risk, suggesting ABI
Area of Science:
- Neurology
- Vascular Medicine
- Stroke Research
Background:
- Ankle-brachial index (ABI) is linked to poorer stroke prognosis and recurrence.
- The association between ABI and early neurological deterioration (END) after acute cerebral infarction remains unclear.
Purpose of the Study:
- To investigate the correlation between ABI values and the risk of END in patients with acute isolated pontine infarction.
Main Methods:
- Prospective analysis of 408 patients with acute isolated pontine infarction and ABI ≤ 1.40.
- Patients categorized into low (≤0.90), borderline (0.91-1.10), and normal (1.11-1.40) ABI groups.
- END defined by NIHSS score changes within the first week.
Main Results:
- 29.4% of patients experienced END.
- Low ABI (≤0.90) was associated with a significantly higher risk of END (OR 1.975).
- Borderline ABI (0.91-1.10) was associated with a significantly lower risk of END (OR 0.457).
Conclusions:
- Low ABI independently predicts an increased risk of END in acute isolated pontine infarction.
- Borderline ABI independently predicts a reduced risk of END in this patient group.
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