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The conflicting role highlights the complexity of GSDMs in cancer
Sijia He1,2, Qian Huang1, Jin Cheng1
1Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Abstract:
Gasdermins (GSDMs) are an important family of proteins that have received extensive attention in tumor research in recent years. They directly induce tumor cell death by mediating pyroptosis and also regulate the recognition and clearance of tumor cells by the immune system by affecting the microenvironment. Therefore, it is of great significance to investigate the role of GSDMs in tumor development and tumor microenvironment. It can not only reveal new mechanisms of cancer development, but also provide theoretical basis for the development of novel anti-tumor therapeutic strategies. This literature review aims to systematically summarize the dual roles of GSDMs in tumor development and their interactions with the tumor microenvironment, and to focus on the importance of GSDM-mediated pyroptosis in anti-cancer therapy, with a view to providing guidance for future research directions.
Insights
Gasdermins (GSDMs) are key proteins in tumor research, inducing cancer cell death via pyroptosis. Understanding GSDMs
Area of Science:
- Oncology and Immunology
- Molecular Biology
- Cancer Research
Background:
- Gasdermins (GSDMs) are emerging as critical regulators in cancer biology.
- These proteins play a dual role in tumor progression and immune surveillance.
- Their involvement in pyroptosis, a programmed cell death pathway, is of significant interest.
Purpose of the Study:
- To systematically review the multifaceted roles of GSDMs in tumor development.
- To elucidate the intricate interactions between GSDMs and the tumor microenvironment.
- To highlight the therapeutic potential of GSDM-mediated pyroptosis in anti-cancer strategies.
Main Methods:
- Literature review and systematic analysis of existing research on Gasdermins.
- Examination of studies focusing on GSDM function in various cancer types.
- Analysis of the impact of GSDMs on the tumor microenvironment and immune response.
Main Results:
- GSDMs directly induce tumor cell death through pyroptosis, acting as tumor suppressors.
- GSDMs modulate the tumor microenvironment, influencing immune cell recognition and clearance of cancer cells.
- Dysregulation of GSDMs can promote tumor growth and metastasis.
Conclusions:
- GSDMs exhibit significant dual roles in cancer development, acting as both promoters and suppressors.
- Targeting GSDM-mediated pyroptosis presents a promising avenue for novel anti-cancer therapies.
- Further research into GSDM-TME interactions is crucial for developing effective cancer treatments.
