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Related Experiment Video

Updated: May 6, 2026

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm

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Published on: April 28, 2016

The Great Mimicker: Forgotten but not Gone.

Blayne E Fenner¹, Kevin M Burningham², Jamael L Thomas³

¹Department of Internal Medicine, Dell Medical School University of Texas, Austin, Tex.

American Journal of Medicine Open

|April 9, 2025

Summary

This summary is machine-generated.

Syphilis is re-emerging globally, often misdiagnosed due to its varied symptoms. Early consideration of syphilis in patients with skin issues is crucial for timely diagnosis and treatment.

Keywords:

Cutaneous lymphoma Secondary syphilis Sexually transmitted infection Syphilis Treponema pallidum

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Area of Science:

Infectious Diseases
Dermatology
Public Health

Background:

Syphilis incidence is rising globally, challenging its historical control with penicillin.
The disease is known as "the great imitator" due to its diverse clinical presentations, especially in the secondary stage.

Observation:

Two cases are presented where syphilis was misdiagnosed, resulting in delayed treatment and unnecessary therapies.
Delayed diagnosis was attributed to the variable and non-specific symptoms of syphilis.

Findings:

Misdiagnosis of syphilis leads to prolonged patient suffering and increased healthcare costs.
Treponemal tests are essential for accurate syphilis diagnosis when clinical presentation is ambiguous.

Implications:

Healthcare providers should maintain a high index of suspicion for syphilis, particularly with diffuse cutaneous eruptions.
Public health strategies may need re-evaluation to address the resurgence of syphilis.
Timely and accurate diagnosis of syphilis is critical to prevent complications and control transmission.