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Successful Treatment of Extensively Drug-Resistant Acinetobacter baumannii Intracranial Infection with Meropenem and

Wenke Ma1, Chao Zhang1, Bei He1

  • 1Department of Neurosurgery, Baoji Central Hospital, Baoji, Shaanxi, People's Republic of China.

Infection and Drug Resistance
|April 9, 2025
PubMed
Abstract

Insights

Extensively drug-resistant Acinetobacter baumannii intracranial infections are challenging. Meropenem plus cefoperazone sodium sulbactam offers a potential treatment strategy for these difficult-to-treat infections.

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Pharmacology

Background:

  • Intracranial infections caused by multidrug-resistant (MDR) or extensively drug-resistant (XDR) Acinetobacter baumannii present significant therapeutic challenges.
  • Poor penetration of antibiotics across the blood-brain barrier (BBB) and increasing bacterial resistance complicate treatment strategies.
  • Effective therapeutic schedules for Acinetobacter baumannii intracranial infections are urgently needed.

Observation:

  • A case of XDR Acinetobacter baumannii intracranial infection is presented.
  • The patient had a history of severe traumatic brain injury, cerebrospinal fluid (CSF) rhinorrhea, and severe pneumonia.
  • The infection was successfully treated with a combination of meropenem and cefoperazone sodium sulbactam.

Findings:

  • Meropenem combined with cefoperazone sodium sulbactam demonstrated efficacy against XDR Acinetobacter baumannii.
  • This combination therapy provides a viable option for managing challenging intracranial infections.

Implications:

  • The findings suggest that meropenem and cefoperazone sodium sulbactam can be a valuable therapeutic option for intracranial XDR Acinetobacter baumannii infections.
  • This approach may help overcome treatment limitations associated with drug resistance and BBB penetration.
  • Further research into optimal dosing and treatment durations is warranted.
Keywords:
Acinetobacter baumanniicefoperazone sodium sulbactamextensively drug-resistantintracranial infectionmeropenem

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