Related Experiment Video
Updated: Jun 19, 2026

Dissecting the Non-human Primate Brain in Stereotaxic Space
Published on: July 16, 2009
Age-related alterations in functional and structural networks in the brain in macaque monkeys
Kazuya Ouchi1,2, Shinya Yamamoto1,3, Makoto Obara4
1Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan.
Abstract:
Resting-state networks (RSNs) have been used as biomarkers of brain diseases and cognitive performance. However, age-related changes in the RSNs of macaques, a representative animal model, are still not fully understood. In this study, we measured the RSNs in macaques aged 3-20 years and investigated the age-related changes from both functional and structural perspectives. The proportion of structural connectivity in the RSNs relative to the total fibers in the whole brain significantly decreased in aged macaques, whereas functional connectivity showed an increasing trend with age. Additionally, the amplitude of low-frequency fluctuations tended to increase with age, indicating that resting-state neural activity may be more active in the RSNs may increase with age. These results indicate that structural and functional alterations in typical RSNs are age-dependent and can be a marker of aging in the macaque's brain.
More Related Videos
09:01A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
Published on: May 7, 2014
04:02Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses
Published on: January 17, 2025
Related Concept Videos
Functional Brain Systems: Limbic System
Neuroplasticity
Organization of the Brain
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Piaget's Theory of Cognitive Development from Childhood into Adulthood
Schemata: Building Blocks of Knowledge
Schemata...
Cognitive Development During Adolescence
Information Processing Approach