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Updated: May 15, 2025
Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
Published on: August 4, 2018
Antimicrobial p-terphenyl derivatives from the deep-sea cold seep-derived fungus Aspergillus candidus
Yi-Yi Liu1,2, Jing-Ya Shi3, Qi-Ran Liang1,2
1Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou, Hainan, China.
Abstract:
Four new p-terphenyl derivatives named phenylcandilides C-F, together with nine known analogues, were isolated from the deep-sea cold-seep-derived fungus Aspergillus candidus HNNU0546. Compounds 10 and 12 exhibited antibacterial activity against Staphylococcus aureus with MIC values of 21.6 and 23.6 µM, respectively. Compound 5 showed antifungal activity with an EC50 value of 3.0 µM against phytopathogenic fungus Alternaria sp., while compound 6 exhibited inhibitory activity against Curvularia australiensis and Alternaria sp. with the same EC50 values of 3.0 µM, respectively.
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