High-strength bone polyurethane adhesive with rapid curing for bone tissue injury repair

Area of Science:

• Biomaterials Science
• Orthopedic Surgery
• Polymer Chemistry

Background:

• Current bone tissue adhesives lack sufficient biological safety and mechanical strength.
• Existing commercial options are inadequate for complex bone repair needs, particularly for comminuted fractures.

Purpose of the Study:

• To develop and screen a novel, rapidly cured, high-strength polyurethane bone adhesive.
• To address the limitations of existing bone adhesives in terms of safety and mechanical properties.

Main Methods:

• Development of a polyurethane bone adhesive with an unsaturated ester-modified secondary amine curing agent.
• Utilized Michael addition reaction for rapid and safe curing.
• Evaluated mechanical properties including tensile and compressive moduli, and adhesive strength.

Main Results:

• The developed polyurethane bone adhesive exhibits rapid curing times (236-273 s).
• Achieved high tensile moduli (425.88-666.38 MPa), compressive moduli (214.67-450.66 MPa), and adhesive strengths (0.92-5.86 MPa).
• Demonstrated durability under cyclic stress (0.01-1 MPa for 1000 cycles) and effective in vivo repair functionality.

Conclusions:

• The novel polyurethane bone adhesive provides a superior alternative to current commercial bone cements.
• Offers enhanced mechanical strength, rapid curing, and improved biological safety for bone tissue repair.
• Presents a promising solution for traumatic bone injuries, including comminuted fractures.