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Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

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Updated: May 15, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

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Immune Checkpoint Inhibitor-Induced Lipodystrophy

Julia Riganti¹, Ana C Torre¹, Pietro Sollena²

¹Dermatology Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

JAMA Dermatology

|April 9, 2025

Summary

No abstract available in PubMed .

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