Interplay between gut microbiota and exosome dynamics in sleep apnea
Rebecca Hicks1, David Gozal2, Sarfraz Ahmed1
1Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, 25755, USA.
Sleep Medicine
|April 9, 2025
Summary
Sleep-disordered breathing (SDB) is linked to gut microbiota (GM) changes. Targeting GM and exosomes may offer new therapeutic strategies for SDB management.
Area of Science:
- Microbiology
- Sleep Medicine
- Gastroenterology
Background:
- Sleep-disordered breathing (SDB) involves airflow interruptions during sleep, impacting health and cognition.
- Emerging research highlights a connection between gut microbiota (GM) and SDB.
- The gut-brain axis and intestinal barrier integrity (
Purpose of the Study:
- To review the current understanding of the relationship between GM, exosomes, and SDB.
- To explore potential mechanisms and therapeutic implications.
Main Methods:
- Comprehensive literature review.
- Focus on studies investigating GM composition, intestinal barrier function, and gut-brain communication in SDB.
Main Results:
- Evidence suggests associations between SDB and GM diversity/bacterial shifts.
- The concept of
Conclusions:
- The gut microbiota and exosomes are implicated in SDB pathophysiology.
- Targeting GM and exosomes presents promising therapeutic avenues for SDB.
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