A multi-modal embolic gel system for long-term fluorescence imaging and photothermal therapy

Gel embolic agents are increasingly recognized for their versatility in minimally invasive vascular interventions. However, their application in real-time imaging, post-operative monitoring, and thermal treatment remains underexplored. In this study, we present a novel transcatheter injectable nanoclay-alginate (NCA) gel embolic agent integrated with indocyanine green (ICG) for dual fluorescence imaging and thermal ablation. The NCA/ICG embolic gel exhibits excellent shear-thinning properties, transcatheter injectability, and mechanical stability. Furthermore, the mechanism to enhance fluorescence for real-time imaging enhancement and extended post-operative monitoring was discussed. A 28-day fluorescence persistence shows the NCA/ICG gel's long-lasting fluorescent signal, which was significantly stronger and longer compared to current clinically used ICG aqueous solution. Furthermore, the gel can effectively convert near-infrared (NIR) laser energy into heat for potential photothermal therapy. The biocompatibility and enhanced antibacterial properties further highlight the potential clinical benefits of this embolic agent as a multifunctional agent for vascular embolization.