Spontaneous hematomyelia secondary to factor XI deficiency. Case report

Area of Science:

• Neurology
• Hematology
• Spinal Cord Medicine

Background:

• Factor XI deficiency is a rare inherited bleeding disorder.
• Spinal cord кровоизлияние (hematomyelia) can lead to severe neurological deficits.
• Spontaneous hematomyelia, without trauma, is exceptionally uncommon.

Observation:

• A 34-year-old female patient with known Factor XI deficiency presented with a week of neck pain.
• Rapidly progressive quadriplegia developed, indicating a critical neurological event.
• Surgical exploration revealed a spontaneous hematomyelia at the C4-6 vertebral level.

Findings:

• The patient's symptoms were attributed to an intraspinal hemorrhage.
• Successful evacuation of the hematoma was performed.
• The case underscores the potential for spontaneous bleeding in Factor XI deficiency.

Implications:

• This case expands understanding of Factor XI deficiency complications.
• It highlights the importance of considering hematomyelia in patients with bleeding disorders and neurological decline.
• Further research into the pathophysiology of spontaneous spinal hematomyelia is warranted.