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Updated: May 15, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Synthesis of benzoheterocycles by palladium-catalyzed migratory cyclization through an unexpected reaction cascade
Wen-Cong Li1,2,3,4, Lin Zhang2, Shiming Bai4
1Inner Mongolia Key Laboratory of Low Carbon Catalysis, Inner Mongolia Key Laboratory of Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, China.
Abstract:
Migratory functionalization of C-H bonds through metal migration from carbon to carbon under transition metal catalysis is a process of significant academic and industrial interest. Herein, a palladium-catalyzed migratory cyclization of α-bromoalkene derivatives ArXCBr=CH2, in which X denotes a phosphorus (P(O)R), silicon (SiR2), sulfur (SO2), carbon (C(O)), nitrogen (NTs), or oxygen-based moiety, affording various benzoheterocyclic compounds has been developed. Mechanistic investigations have demonstrated that the cyclization reaction proceeds through an unexpected cascade, with trans-1,2-palladium migration between sp2 carbons being a key step of catalytic cycle. To the best of our knowledge, this type of metal migration has not been reported previously.
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