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Updated: May 15, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

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The current state and implications of pre-operative fasting time in children: a systematic review and meta-analysis

Leyao Han1,2, Yingqiao Wang1,3, Juanping Zhong4

  • 1School of Nursing, Lanzhou University, Lanzhou, China.

Pediatric Surgery International
|April 9, 2025
PubMed

Insights

Children

Area of Science:

  • Pediatric Anesthesiology
  • Perioperative Care
  • Evidence-Based Medicine

Background:

  • Prolonged pre-operative fasting in children may compromise hemodynamic stability and patient satisfaction.
  • Current fasting guidelines for pediatric patients undergo frequent revisions.
  • Clinical practice adherence to updated fasting protocols requires investigation.

Purpose of the Study:

  • To evaluate current pre-operative fasting durations for children.
  • To assess the implementation of international fasting guidelines in clinical settings.
  • To identify discrepancies between recommended and actual fasting times.

Main Methods:

  • A comprehensive literature search was conducted until March 27, 2024.
  • Meta-analysis of 10 cross-sectional studies involving 1694 (solids) and 3527 (liquids) children.
  • Quality assessment using the JBI cross-sectional study tool and random effects meta-regression.

Main Results:

  • Mean pre-operative solids fasting time was 12.69 hours (CI: 11.96-13.43).
  • Mean pre-operative liquids fasting time was 8.38 hours (CI: 6.03-10.73).
  • Both fasting durations significantly exceeded twice the recommended times in international guidelines.

Conclusions:

  • Pediatric pre-operative fasting durations in clinical practice deviate substantially from international guidelines.
  • Evidence-based interventions are necessary to align clinical practices with established guidelines.
  • Further research should explore barriers to guideline adherence and propose solutions.

Keywords:
ChildrenGuidelineLiquidPreoperative fasting timeSolid

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