The progress of hyaluronic acid's application in therapeutic delivery

Hyaluronic acid (HA) is a widely available, bio-compatible, polysaccharide with unique physical and chemical properties, which have inspired its application in many fields. Firstly, HA is a significant representative in wound healing, embryonic development, repair as well as regeneration. Secondly, HA exhibits pregnant meaning in cancer progression. Tumor cell proliferation, invasiveness, and motility can be modulated by the accumulation of HA in tumor stoma. Thirdly, HA is an actor in regulation processes during the angiogenesis. The level of HA, even low-molecular-weight HA, is considered to be a biomarker of tumor malignancy. Within this work, an intense overview of its application and the use of HA in drug delivery systems is given.HA plays a crucial role in many cases, such as cell signaling, morphogenesis, matrix organization, tissue regeneration, and pathobiology. Biocompatibility, mucoadhesivity, hygroscopicity, biodegradability, and viscoelasticity are to mention as physico-chemical properties of hyaluronan. This is why exogenous HA is investigated for drug delivery systems and exhibits a representative therapy of cancer, esthetic medicine, rhinology, arthrology, and cosmetics.In the end, the proof of concept presented by clinical trials is convincing to further investigate native HA as well as modified one for therapeutic delivery purposes.