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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: May 15, 2025

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Published on: August 13, 2014

Organ preservation: current limitations and optimization approaches.

Qiulin Ran¹, Jiayi Zhang², Jisheng Zhong¹

¹Department of Cardiovascular Surgery, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Frontiers in Medicine

|April 10, 2025

Summary

This summary is machine-generated.

Organ transplantation faces graft shortages due to preservation issues. Machine perfusion (MP) offers a promising alternative to static cold storage (SCS) for improving graft viability and transplant outcomes.

Keywords:

graft quality machine perfusion organ preservation organ repair static cold storage transplantation

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Last Updated: May 15, 2025

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Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

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Published on: July 15, 2015

Area of Science:

Transplantation immunology
Organ preservation science
Regenerative medicine

Background:

Graft scarcity limits organ transplantation, driven by donor limitations, preservation challenges, and immunologic mismatch.
Current static cold storage (SCS) faces limitations including cold-induced injury, solution toxicity, and exacerbation of reperfusion injury.
Marginal organs and extended criteria donors (ECD) present challenges for traditional preservation methods.

Purpose of the Study:

To review advancements in organ preservation techniques, focusing on static cold storage (SCS) and dynamic machine perfusion (MP).
To elucidate injury mechanisms associated with SCS and explore optimization strategies.
To highlight the potential of MP in enhancing graft utilization and post-transplant outcomes.

Main Methods:

Comprehensive literature review of organ preservation strategies, including cryopreservation, subzero non-freezing storage, SCS, and MP.
Analysis of injury mechanisms inherent to SCS.
Evaluation of MP technologies and their benefits for graft viability and repair.

Main Results:

SCS, while cost-effective, can induce cold injury and fails to address reperfusion damage.
Dynamic machine perfusion (MP) preserves organs in a near-physiological state, allowing for viability assessment and damage repair.
MP is increasingly adopted, especially for ECDs, offering improved outcomes compared to SCS.

Conclusions:

Advancements in MP technology are crucial for overcoming limitations of SCS and improving organ transplant success.
Understanding SCS injury mechanisms can inform the optimization of MP protocols.
MP holds significant promise for expanding the donor pool and enhancing graft survival rates.