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Related Concept Videos

Obesity01:24

Obesity

347
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Related Experiment Video

Updated: May 15, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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Association between novel adiposity parameters and hyperuricemia: a cross-sectional study.

Baoan Wang1,2, Chuncheng Ma1,2, Jinhua Wu1,2

  • 1Affiliated Jiangmen TCM Hospital of Ji'nan University, Jiangmen, Guangdong, China.

Frontiers in Nutrition
|April 10, 2025
PubMed
Summary

Novel obesity metrics like body roundness index (BRI) are linked to higher hyperuricemia risk. BRI shows strong diagnostic value for hyperuricemia, offering a new evaluation tool.

Keywords:
National Health and Nutrition Examination Surveyadiposity parametersbody roundness indexcross-sectional studyhyperuricemia

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Area of Science:

  • Metabolic Health
  • Obesity Research
  • Epidemiology

Background:

  • Body mass index (BMI) has limitations in assessing body fat distribution.
  • Novel adiposity parameters offer potential improvements over BMI for obesity assessment.
  • Hyperuricemia is a metabolic condition associated with various health risks.

Purpose of the Study:

  • To investigate the association between novel adiposity parameters and hyperuricemia.
  • To evaluate the diagnostic value of these parameters for hyperuricemia.
  • To identify potential new indices for hyperuricemia evaluation.

Main Methods:

  • Utilized data from the National Health and Nutrition Examination Survey (1999-2006).
  • Employed weighted logistic regression to analyze relationships between hyperuricemia and parameters like BRI, WWI, ABSI, and CoI.
  • Used receiver operating characteristic (ROC) curve analysis to determine diagnostic power (AUC).

Main Results:

  • A total of 24,763 participants were included, with 3,528 diagnosed with hyperuricemia.
  • Higher quartiles of BRI, WWI, ABSI, and CoI were significantly associated with increased hyperuricemia risk.
  • Body Roundness Index (BRI) demonstrated the highest diagnostic value (AUC = 0.697 for males, 0.751 for females).

Conclusions:

  • Increased novel obesity parameters correlate with a higher risk of hyperuricemia in the general population.
  • BRI shows significant diagnostic utility and can serve as a novel index for hyperuricemia assessment.
  • Findings support BRI as a valuable tool for hyperuricemia prevention and monitoring.