Related Experiment Video

Updated: May 15, 2025

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
13:18

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

1.1K

The polyphenolic compound, α-conidendrin, exerts anti-colon cancer and anti-angiogenic effects by targeting several

Sayeh Mottaghi1, Hassan Abbaszadeh2, Armita Valizadeh3

  • 1Department of Pediatrics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Naunyn-Schmiedeberg'S Archives of Pharmacology
|April 10, 2025
PubMed

Insights

Alpha-conidendrin shows strong anti-colon cancer effects by inducing apoptosis and inhibiting proliferation. It also exhibits anti-angiogenic properties, making it a promising agent for colon cancer treatment.

Area of Science:

  • Pharmacology
  • Oncology
  • Molecular Biology

Background:

  • Previous research indicated alpha-conidendrin's anti-proliferative effects on breast cancer cells.
  • Colon cancer remains a significant global health challenge requiring novel therapeutic strategies.

Purpose of the Study:

  • To evaluate the anti-colon cancer and anti-angiogenic potential of alpha-conidendrin.
  • To elucidate the molecular mechanisms underlying its effects on colon cancer cells and angiogenesis.

Main Methods:

  • In vitro studies using HT-29 colon cancer cells and endothelial cells.
  • Analysis of protein and mRNA expression related to apoptosis and angiogenesis pathways.
  • Assessment of cell proliferation and apoptosis induction.
  • Ex vivo and in vitro angiogenesis models.

Main Results:

  • Alpha-conidendrin significantly inhibited colon cancer cell proliferation and induced caspase-mediated apoptosis.
  • It modulated the PTEN/PI3K/Akt/mTOR pathway, upregulating PTEN and downregulating p-PI3K, p-Akt, and p-mTOR.
  • Protein expression of caspase-3 and caspase-9 was enhanced.
  • Anti-angiogenic effects were observed, with downregulated mRNA expression of HIF-1α, VEGF, MMP-2, and MMP-9 in endothelial cells.

Conclusions:

  • Alpha-conidendrin demonstrates potent anti-colon cancer and anti-angiogenic activities.
  • The compound acts through mechanisms involving apoptosis induction and modulation of key signaling pathways.
  • Alpha-conidendrin represents a promising novel agent for colon cancer therapy.
Keywords:
Anti-angiogenicAnti-colon cancerMechanisms of actionα-Conidendrin

More Related Videos

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.4K
Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

19.0K

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.0K
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
105.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.6K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K