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Updated: May 23, 2025
06:04
Surgical Treatment for Benign Prostatic Hyperplasia: Holmium Laser Enucleation of the Prostate HoLEP.
Published on: March 6, 2018
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Opioid prescribing patterns following surgical interventions for benign prostatic hyperplasia
Laura E Gressler1, Christina Sze2, Ananth Punyala3
1Division of Pharmaceutical Evaluation and Policy, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Summary
Men undergoing surgery for benign prostatic hyperplasia (BPH) in operating rooms (OR) received more opioid prescriptions post-surgery. This suggests potential overprescription, highlighting a need for improved pain management strategies and non-opioid alternatives.
Area of Science:
- Urology
- Pain Management
- Pharmacology
Background:
- Benign prostatic hyperplasia (BPH) is a common condition requiring surgical intervention.
- Postoperative pain management following BPH surgery is critical.
- Understanding opioid prescribing patterns is essential for optimizing patient care.
Purpose of the Study:
- To analyze and compare opioid prescribing behavior after surgical interventions for BPH.
- To investigate differences in postoperative opioid use between operative room (OR) and non-operative room (non-OR) surgical settings.
Main Methods:
- Retrospective cohort study utilizing IQVIA PharMetrics® Plus database (2015-2020).
- Included 6022 men undergoing surgical interventions for BPH.
- Propensity score analysis and inverse probability treatment weighting adjusted for confounders.
Main Results:
- Patients undergoing BPH surgery in OR settings had higher opioid prescription rates (42.78%) compared to non-OR settings (28.00%).
- Adjusted models showed significantly higher odds of opioid prescription for OR procedures (OR 1.922).
- No significant differences in cumulative days or morphine equivalent daily dose (MEDD) were observed, but prescription duration distribution differed.
Conclusions:
- BPH surgeries in OR settings are associated with increased likelihood of postoperative opioid prescriptions.
- Findings suggest potential overprescription and the need for enhanced pain management strategies.
- Recommendations include exploring non-opioid alternatives and further research into actual opioid consumption and patient-specific factors.
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