Related Experiment Video
Updated: May 15, 2025
08:34
Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
10.1K
Biogenesis and Regulation of Telomerase during Development and Cancer
Lu Chen1, Luis Francisco Zirnberger Batista2,3
1Cancer Signaling and Epigenetics Program and Cancer Epigenetics Institute, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA lu.chen@fccc.edu lbatista@wustl.edu.
Cold Spring Harbor Perspectives in Biology
|April 10, 2025
Summary
Telomerase, crucial for maintaining chromosome ends, is vital for cell health. Understanding its assembly and biogenesis offers new therapeutic strategies for telomere biology disorders.
Area of Science:
- Molecular Biology
- Genetics
- Cell Biology
Background:
- Telomerase is a ribonucleoprotein complex essential for adding telomeric DNA repeats to chromosome ends.
- Its activity is tightly regulated, often upregulated in cancer cells, while defects lead to telomere biology disorders.
Purpose of the Study:
- To discuss the current understanding of telomerase holoenzyme biogenesis and assembly.
- To explore how these processes influence telomerase efficiency and are affected by component localization.
- To highlight recent advances in telomerase biogenesis for potential clinical applications.
Main Methods:
- Review of current literature on telomerase biogenesis and assembly.
- Analysis of the role of subcellular localization in holoenzyme formation.
- Discussion of recent discoveries and their clinical implications.
Main Results:
- Telomerase biogenesis and assembly are central to its efficient function.
- Subcellular localization of components critically impacts holoenzyme formation.
- Recent progress has illuminated new therapeutic avenues for telomere biology disorders.
Conclusions:
- Proper biogenesis and assembly are key to telomerase function and telomere maintenance.
- Understanding telomerase assembly provides insights into disease mechanisms.
- Advances in telomerase biogenesis research offer promising clinical benefits for patients.
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