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Updated: May 15, 2025

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Rh-Catalyzed Coupling of Cyclic 1,3-Dicarbonyl-Derived Iodonium Ylides with Cyclopropanols
Zongye Wang1, Mingxuan Liang1, Dongyang Zhang1
1Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Abstract:
Herein, we report a modular α-monoalkylation of cyclic 1,3-dicarbonyls with cyclopropyl alcohols through a cyclic iodonium ylide strategy. This approach is general, base-free, operationally simple, and suitable for various medically important (hetero)cyclic 1,3-dicarbonyls. A wide range of cyclopropyl alcohols, easily prepared from feedstock chemicals, can serve as modular and complement alkylating agents. Importantly, the newly formed carbonyl groups in the resulting products provide a versatile platform for numerous synthetic applications.
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