Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

98
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
98
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

28
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
28
Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

52
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
52
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

756
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
756
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

759
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
759
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

102
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
102

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inappropriate antibiotic utilization in hospitalized patients in Ethiopia: A systematic review and meta-analysis.

Exploratory research in clinical and social pharmacy·2026
Same author

Cancer-related fatigue among adult patients living with cancer in Ethiopia: A systematic review and meta-analysis.

Neuro-oncology advances·2026
Same author

A Giant Mesenteric Cystic Lymphangioma Causing Abdominal Mass Effect: A Case Report of a 57-Year-Old Woman.

Case reports in surgery·2026
Same author

Unused medicines among households in internally displacement (IDP) camps in Ethiopia: an explanatory sequential mixed-methods study.

Scientific reports·2026
Same author

Challenges and best practices in essential medicines supply and use in internally displaced persons (IDP) camps: A qualitative study.

Exploratory research in clinical and social pharmacy·2026
Same author

Giant megaureter presenting as femoral hernia: case report.

International journal of surgery case reports·2026

Related Experiment Video

Updated: May 15, 2025

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

9.4K

Herbicide poisoning causing multiple colonic perforations: case report.

Tesfaye Birhanu Abebe1,2, Daba Iticha Ayana3, Dereje Gebisa Bedada4

  • 1Department of Surgery, School of medicine, collage of health sciences, Salale University, P.O.BOX: 245, Fiche, Ethiopia. tesfu13b21@gmail.com.

International Journal of Emergency Medicine
|April 11, 2025
PubMed
Summary

This case report details a rare instance of multiple colonic perforations following 2,4-Dichlorophenoxyacetic acid (2,4-D) herbicide poisoning. Prompt medical intervention and awareness are crucial for managing severe herbicide toxicity.

Keywords:
2,4-Dichlorophenoxyacetic acidCase reportColonic perforationHerbicide poisoningSurgery

More Related Videos

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

27.0K
Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.2K

Related Experiment Videos

Last Updated: May 15, 2025

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

9.4K
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

27.0K
Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.2K

Area of Science:

  • Toxicology
  • Gastroenterology
  • Emergency Medicine

Background:

  • 2,4-Dichlorophenoxyacetic acid (2,4-D) poisoning is a significant cause of systemic toxicity, particularly in agricultural areas.
  • Common symptoms include gastrointestinal, muscular, renal, and neurological effects.
  • Multiple colonic perforations are an exceptionally rare complication of 2,4-D ingestion.

Purpose of the Study:

  • To report a unique case of multiple colonic perforations resulting from 2,4-D ingestion.
  • To emphasize the importance of vigilance and prompt management in herbicide poisoning cases.
  • To highlight the need for community awareness and safe herbicide use guidelines.

Main Methods:

  • A 19-year-old male farmer presented after ingesting 2,4-D solution, exhibiting symptoms of poisoning.
  • The patient was treated for hypovolemic shock, aspiration pneumonia, and coma.
  • Diagnosis of multiple colonic perforations was made 14 days post-ingestion, leading to surgical intervention (total colectomy with ileostomy).

Main Results:

  • The patient developed peritonitis 14 days after 2,4-D ingestion.
  • Multiple colonic perforations were discovered and surgically treated.
  • This represents the first documented human case of multiple colonic perforations due to 2,4-D poisoning.

Conclusions:

  • Vigilance and prompt management are critical for improving outcomes in patients with multiple colonic perforations from herbicide poisoning.
  • Raising community awareness about herbicide risks is essential.
  • Establishing guidelines for safe herbicide use can help prevent such severe poisoning incidents.