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Recent Advances in Field-Effect Transistor-Based Biosensors for Label-Free Detection of SARS-CoV-2
Haiyang Yu1,2, Huibin Zhang3, Zhe Liu2
1Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China.
Small Science
|April 11, 2025
Summary
Field-effect transistor (FET) biosensors offer sensitive, label-free detection of SARS-CoV-2. This review analyzes advances in electrochemical FET biosensors for COVID-19 diagnostics and future development.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Infectious Disease Diagnostics
Background:
- Field-effect transistor (FET) biosensors are crucial for sensitive, label-free detection.
- The SARS-CoV-2 pandemic highlighted the need for rapid diagnostic tools.
- Electrochemical FET biosensors show promise for detecting viral pathogens.
Purpose of the Study:
- To review recent advances in electrochemical FET biosensors for SARS-CoV-2 detection.
- To analyze the technical requirements, designs, and interface engineering of these biosensors.
- To provide insights into future development for in vitro diagnostics.
Main Methods:
- Comprehensive literature review of electrochemical FET biosensor systems.
- Analysis of transistor transducer designs and working principles.
- Summary of interface engineering strategies for enhanced sensing.
Main Results:
- Detailed discussion of FET biosensor applications for SARS-CoV-2 detection.
- Identification of critical technical requirements for FET biosensor systems.
- Overview of structural designs and interface engineering for improved performance.
Conclusions:
- Electrochemical FET biosensors are highly sensitive and label-free for SARS-CoV-2 detection.
- Interface engineering is key to optimizing biosensor performance.
- Future development holds potential for impactful health monitoring and diagnostics.
