Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Super-resolution Fluorescence Microscopy

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Super-resolution imaging of limited-size objects.

Nature photonics·2026

Same author

Space-time superoscillations.

Nature communications·2026

Same author

Topological robustness of classical and quantum optical skyrmions in atmospheric turbulence.

Nature communications·2026

Same author

Enhanced Quantum Magnetometry with a Femtosecond Laser-Written Integrated Photonic Diamond Chip.

Nano letters·2025

Same author

Photon number resolution without optical mode multiplication.

Nanophotonics (Berlin, Germany)·2024

Same author

Nondiffracting supertoroidal pulses and optical "Kármán vortex streets".

Nature communications·2024

Same journal

Recent Progress in on-Demand Transfer-Enabled Integration of Wavelength-Scale Light Sources.

Nanophotonics (Berlin, Germany)·2026

Same journal

Tunable skyrmion bag textures in surface phonon polariton lattices.

Nanophotonics (Berlin, Germany)·2026

Same journal

All-Optical Diffractive Operators for Rapid, Computer-Free Morphological Transformations.

Nanophotonics (Berlin, Germany)·2026

Same journal

Tunable Skyrmion, Meron, and Skyrmion Bag Textures in Surface Phonon Polariton Lattices.

Nanophotonics (Berlin, Germany)·2026

Same journal

Deep-Subwavelength Slot-Enhanced Broadband Dynamic Camouflage Metasurface Across the S, C, X, and Ku Bands.

Nanophotonics (Berlin, Germany)·2026

Same journal

Machine Learning-Driven Cooling Window Design Beyond Hyperbolic Metamaterials.

Nanophotonics (Berlin, Germany)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 15, 2025

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Published on: January 3, 2016

Localization of nanoscale objects with light singularities.

Thomas A Grant¹, Anton N Vetlugin², Eric Plum¹

¹Optoelectronics Research Centre, University of Southampton, Southampton, SO17 1BJ, UK.

Nanophotonics (Berlin, Germany)

|April 11, 2025

Summary

This summary is machine-generated.

Optical localization measurements achieve unprecedented atomic-scale resolution using deep learning and structured light. Illuminating nano-objects with light containing phase singularities significantly enhances measurement precision, enabling subwavelength metrology.

Keywords:

nanophotonics; optical metrology singularities superoscillation

More Related Videos

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Optical Trapping of Nanoparticles

Optical Trapping of Nanoparticles

Published on: January 15, 2013

Related Experiment Videos

Last Updated: May 15, 2025

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Published on: January 3, 2016

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Optical Trapping of Nanoparticles

Optical Trapping of Nanoparticles

Published on: January 15, 2013

Area of Science:

Optics
Metrology
Nanotechnology

Background:

Recent advances demonstrate atomic-scale resolution in optical localization using deep learning and structured light.
Topologically structured light, particularly light with phase singularities, offers unique scattering properties.

Purpose of the Study:

To explain the fundamental principles behind enhanced precision in optical localization using structured light.
To investigate the role of phase singularities in improving Fisher information for nano-object metrology.

Main Methods:

Analysis of diffraction patterns from topologically structured light scattered by nano-objects.
Deep learning applied to single-shot optical localization measurements.
Comparison of Fisher information content using plane waves versus light with phase singularities.

Main Results:

Positional changes of an object alter diffraction patterns based on spatial derivatives of the incident field's amplitude and phase.
Phase singularities lead to an orders-of-magnitude increase in Fisher information despite lower intensity.
Deep learning analysis of diffraction patterns enables unprecedented atomic-scale measurement resolution.

Conclusions:

Phase singularities in incident light are crucial for achieving deeply subwavelength precision in metrology.
Singularity-based metrology offers a fundamental pathway to enhanced resolution in optical measurements.
The findings provide a strong motivation for developing and utilizing singularity-based optical measurement techniques.