Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis and comparative study on the influencing factors of bronchopulmonary dysplasia in premature infants with gestational age ≤32 weeks based on logistic regression and decision tree models.

Translational pediatrics·2026
Same author

Intelligent soft robotic gripper for non-destructive grasping and attribute recognition via multi-modal waveguide tactile sensors.

Microsystems & nanoengineering·2026
Same author

Hyperspectral data-driven corn nitrogen monitoring: application and interpretability analysis of multi-source feature optimization and stacked ensemble learning methods.

Frontiers in plant science·2026
Same author

Internal-external dual cross-linked alginate/gelatin composite hydrogel beads: Structure and pH-responsive gastrointestinal delivery of bioactives.

Food chemistry·2026
Same author

Personalized non-invasive continuous glucose monitoring via multiparameter-informed machine learning.

Biosensors & bioelectronics·2026
Same author

Decoding the microbiome: artificial intelligence-targeted gut microenvironment breakthroughs in personalized cancer therapy.

Gut microbes·2026

Related Experiment Video

Updated: May 15, 2025

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements
05:49

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Published on: December 2, 2022

2.6K

Multiplexed Single-Cell Rheology Probing Using Surface Acoustic Waves.

Yi Hu1, Yulin Wang1, Meiru Zhang1

  • 1State Key Laboratory of Precision Measurement Technology and Instruments Tianjin University Tianjin 300072 China.

Small Science
|April 11, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a novel surface acoustic wave (SAW) method for precise single-cell rheology, revealing complex cellular viscoelastic behaviors and negative plastic compliance in adherent cells.

Keywords:
cell rheology measurementpower‐law dynamicssurface acoustic wavestargeted microbeads

More Related Videos

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics
12:26

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics

Published on: August 27, 2013

17.0K
Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations
06:51

Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations

Published on: August 21, 2018

6.9K

Related Experiment Videos

Last Updated: May 15, 2025

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements
05:49

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Published on: December 2, 2022

2.6K
Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics
12:26

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics

Published on: August 27, 2013

17.0K
Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations
06:51

Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations

Published on: August 21, 2018

6.9K

Area of Science:

  • Biophysics
  • Cellular Mechanics
  • Microfluidics

Background:

  • Cellular rheology is crucial for cell function and status.
  • Probing rheology in adherent cells with high control is challenging.
  • Existing methods lack multiplexing and precise manipulation capabilities.

Purpose of the Study:

  • To develop a highly controllable, multiplexed method for single-cell rheology.
  • To investigate the viscoelastic properties of adherent cells.
  • To explore cellular biomechanics at the micro and sub-cellular levels.

Main Methods:

  • Utilized a surface acoustic wave (SAW) device integrated into a microfluidic chamber.
  • Employed cell-anchored microbeads to concentrate acoustic energy for cell deformation.
  • Developed strategies for precise microbead placement on the cell membrane.
  • Applied power-law rheological models to analyze creep and relaxation responses.

Main Results:

  • Successfully performed over 400 multiplexed rheology measurements on adherent cells.
  • Observed a wide range of viscoelastic behaviors, exceeding previously reported dynamics.
  • Detected unexpected negative plastic compliance in cellular responses.
  • Demonstrated high controllability and precision in cell deformation.

Conclusions:

  • The SAW-based method enables in-depth investigation of cellular biomechanics.
  • The findings expand the understanding of adherent cell rheology.
  • This technique holds potential for regulating cell function through mechanical forces.