Novel Strategy for Optimized Nanocatalytic Tumor Therapy: From an Updated View

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Nanozymes offer tunable catalytic performance and biocompatibility for biomedical uses like biosensors and antitumor agents.
• Nanocatalytic therapy (NCT) utilizes nanozyme-based Fenton reactions for tumor treatment.
• Modulating the tumor microenvironment (TME) is key to enhancing NCT efficiency.

Purpose of the Study:

• To provide updated insights into novel strategies for effective nanocatalytic reactions in NCT.
• To analyze the design and formulation of multifunctional nanozyme systems for targeted and synergistic cancer therapy.
• To explore theranostic applications and outline future perspectives for NCT's biomedical translation.

Main Methods:

• Reviewing recent advancements in nanozyme modification for enhanced nanocatalysis.
• Analyzing TME-modulating approaches to improve in situ tumor suppression.
• Examining the formulation of multifunctional nanozyme-based systems for targeted therapy and theranostics.

Main Results:

• Novel strategies focus on optimizing nanocatalyst performance and TME modulation for superior NCT.
• Multifunctional nanozyme systems are being developed for targeted, synergistic therapy and theranostic applications.
• Significant progress has been made in translating NCT for improved cancer treatment.

Conclusions:

• Further research is needed to overcome challenges in the biomedical translation of NCT.
• Optimizing nanozyme design and TME modulation holds great promise for advanced cancer therapy.
• Multifunctional nanozyme systems offer versatile solutions for targeted and theranostic applications in oncology.