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Updated: May 14, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Kinetic Resolution to Simultaneously Access Both Primary and Secondary NH-Unprotected Chiral Amines via Ir-Catalyzed
Junbin Shi1, Shaoxiong Wu1, Haizhou Huang1
1College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China.
Abstract:
This report describes a new kinetic resolution-asymmetric reductive amination strategy to collectively gain access to both primary and secondary chiral NH-unprotected amines. Catalyzed by the complex of iridium and bulky and tunable phosphoramidite ligands, various ketones and racemic primary amines could be smoothly converted to two different types of amine products. Bronsted acids as additives play triple roles, decreasing the inhibitory effect, promoting the formation of the imine intermediates, and guiding the reaction to proceed through "outer-sphere" H-addition along with the bulky ligand.
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