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Acute Gastroenteritis Is a Risk Factor for the Development of Disorders of Gut-Brain Interaction in Children

Aishwarya Palorath1, Claire Narang2, Lourdes Forster3

  • 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Miami, Miller School of Medicine, Miami, Florida, USA.

The American Journal of Gastroenterology
|April 11, 2025
PubMed

Insights

Children who experience acute gastroenteritis (AGE) are at higher risk of developing disorders of gut-brain interactions (DGBIs). The severity of AGE symptoms directly correlates with the increased likelihood of developing post-infectious DGBIs (PI-DGBI).

Area of Science:

  • Pediatric Gastroenterology
  • Gut-Brain Axis Research
  • Infectious Disease Epidemiology

Background:

  • Acute gastroenteritis (AGE) is a common precursor to disorders of gut-brain interactions (DGBIs) in adults, termed post-infectious DGBI (PI-DGBI).
  • Limited data exists on the incidence and risk factors for PI-DGBI development in pediatric populations.
  • This study investigates the link between AGE and DGBI development in children.

Purpose of the Study:

  • To determine if AGE predisposes children to developing DGBIs.
  • To evaluate the association between AGE severity and the subsequent development of DGBIs in children.

Main Methods:

  • A prospective, controlled cohort study design was employed.
  • Children with recent AGE (cases) and their siblings (controls) were followed for six months.
  • Disorders of gut-brain interactions were assessed using the validated QPGS IV questionnaire based on Rome criteria.

Main Results:

  • At three months, 20.4% of children with AGE developed DGBIs compared to 1.8% of controls (P=0.00).
  • Among those without prior DGBI history, 12.2% of cases developed DGBI versus 0% of controls (P=0.01).
  • Severity of AGE symptoms showed a significant correlation with PI-DGBI development (ρ=0.707, P=0.00).

Conclusions:

  • Children experiencing acute gastroenteritis have a significantly higher likelihood of developing DGBIs.
  • The severity of acute gastroenteritis is a key risk factor associated with the development of PI-DGBI in children.
Abstract

Keywords:
childrendisorders of gut-brain interactiongastroenteritispostinfection

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