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GLP-1-Mediated Targeting of Inflammation Corrects Obesogenic Memory in Male Mice

Stéphane Léon1, Julie Benoit1, Samantha Clark1

  • 1University of Bordeaux, INSERM, Neurocentre Magendie, U1215, Bordeaux, France.

Diabetes
|April 11, 2025
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Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
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