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Alpha-Fetoprotein (AFP) biosensors.

Nava Moghadasian Niaki1, Faezeh Hatefnia1, Mohammad Mahdi Heidari2

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Clinica Chimica Acta; International Journal of Clinical Chemistry
|April 11, 2025
PubMed
Summary
This summary is machine-generated.

Alpha-fetoprotein (AFP) detection is vital for liver cancer diagnosis. Advanced biosensors offer a sensitive, rapid, and user-friendly alternative to traditional methods for AFP measurement.

Keywords:
Alpha-fetoproteinBiomarkerBiosensorELISANanomaterials

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Area of Science:

  • Biochemistry
  • Biotechnology
  • Medical Diagnostics

Background:

  • Alpha-fetoprotein (AFP) is a key biomarker for liver diseases, particularly hepatocellular carcinoma (HCC) and germ cell tumors.
  • Elevated AFP levels necessitate accurate and timely measurement for effective disease management.
  • Traditional AFP detection methods like ELISA have limitations in speed, complexity, and equipment requirements.

Purpose of the Study:

  • To explore the role of Alpha-fetoprotein (AFP) in disease diagnosis.
  • To review traditional and emerging biosensing technologies for AFP detection.
  • To discuss recent advancements, challenges, and future prospects in AFP biosensing.

Main Methods:

  • Review of scientific literature on AFP structure, function, and disease association.
  • Analysis of various biosensing platforms (electrochemical, optical, piezoelectric) for AFP detection.
  • Evaluation of molecular recognition elements (antibodies, aptamers, nanoparticles) used in biosensors.

Main Results:

  • Biosensing technologies provide enhanced sensitivity, real-time monitoring, and ease of use for AFP detection.
  • Diverse biosensor platforms demonstrate potential for rapid and specific AFP identification.
  • Recent advancements focus on improving performance and clinical applicability of AFP biosensors.

Conclusions:

  • Biosensors represent a significant advancement over traditional methods for AFP measurement.
  • Further development of cost-effective, portable, and multiplexed AFP biosensors is crucial.
  • AFP biosensing holds transformative potential for early disease detection and personalized medicine.