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Regulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical application
Yan Pan1,2, Hanqiong Zhou1,2, Zhenqiang Sun3
1Department of Internal Medicine, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450008, China.
Cell Death & Disease
|April 11, 2025
Summary
Regulatory T cells suppress anti-tumor immunity, aiding tumor progression. Targeting these cells in solid tumors offers a promising avenue for enhancing cancer immunotherapy outcomes.
Area of Science:
- Immunology
- Oncology
- Cancer Research
Background:
- Tumorigenesis involves complex interactions between tumor cells and the immune system.
- Regulatory T cells (Tregs) are crucial for immune homeostasis but can paradoxically promote tumor growth.
- Solid tumors present unique challenges for effective anti-tumor immune responses.
Purpose of the Study:
- To review the multifaceted role of regulatory T cells in solid tumor immunotherapy.
- To explore how Tregs influence prognosis and immune microenvironment remodeling in solid tumors.
- To summarize current clinical applications and future directions for Treg-targeted solid tumor therapies.
Main Methods:
- Literature review focusing on regulatory T cells in solid tumor immunology.
- Analysis of Treg function in relation to tumor progression and immune evasion.
- Examination of clinical trial data and therapeutic strategies involving Tregs.
Main Results:
- Regulatory T cells are more prevalent and mature in hematologic malignancies than solid tumors.
- Treg-mediated immune suppression can significantly hinder anti-tumor immune responses in solid tumors.
- Targeting Tregs shows potential for improving immunotherapy efficacy in solid tumors.
Conclusions:
- Understanding Treg mechanisms is vital for advancing solid tumor immunotherapy.
- Modulating Treg activity could overcome immune resistance and improve patient prognosis.
- Further research and clinical trials are needed to optimize Treg-based therapeutic strategies.
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