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A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
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Gastroesophageal Neuroendocrine Tumors: Outcomes and Management
Christine Son1,2, Joshua Kalapala3, Jeff Leya1
1Edward Hines VA Hospital, Hines, IL 60141, USA.
Journal of Clinical Medicine
|April 12, 2025
Summary
Neuroendocrine tumors (NETs) in veterans show varied outcomes. Combined chemoradiation improved results for high-grade NETs, but further research is needed for poorly differentiated gastrointestinal NETs.
Area of Science:
- Gastroenterology
- Oncology
- Veterans Health
Background:
- Neuroendocrine tumors (NETs) can occur in any organ, commonly affecting the lungs and gastroenteropancreatic (GEP) system.
- Gastrointestinal (GI) NETs are rare, with undefined standard treatments for advanced stages.
- This study reviews GI NETs in veterans and analyzes treatment outcomes.
Purpose of the Study:
- To review gastrointestinal neuroendocrine tumors (GI NETs) in a veteran population.
- To analyze the therapeutic outcomes of GI NETs in veterans.
- To compare institutional findings with existing literature on GI NET epidemiology and treatment.
Main Methods:
- Retrospective review of 61 GI NET cases from 2019-2024.
- Literature review of 27 review papers, 10 outcome studies, 6 case reports, and 1 case series.
- Analysis of incidence, tumor sites, grade, and treatment responses.
Main Results:
- Higher incidence of GI NETs observed at the institution compared to general epidemiology.
- Small intestine NETs were common; colonic and rectal NETs showed good outcomes.
- Gastric NETs were mostly type 1; esophageal NETs showed mixed responses to chemotherapy.
Conclusions:
- Surgery/endoscopic resection is effective for localized tumors.
- Combined chemoradiation significantly improves outcomes for high-grade, poorly differentiated tumors.
- Further research is required for systemic treatment strategies for poorly differentiated GI NETs.
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