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A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
Osteoma in a Domestic Goose: Radiological and Histopathological Evaluation
Michał Gesek1, Adrianna Michniewicz1, Ewa Łukaszuk2
1Department of Pathological Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
Abstract:
The aim of this work was a detailed radiological and histopathological evaluation of a solid tumour that was diagnosed in a 2-year-old goose (Anser domesticus). The radiograph examination showed an osseous change involving the cervical vertebrae. The tumour measuring 15 cm × 10 cm × 9 cm was dense and had well-defined borders, suggesting the presence of calcified bone tissue. Histopathology revealed a well-defined benign neoplasm derived from bone that consisted largely of irregular, disorganized bone trabeculae surrounded by a layer of osteoblasts. The tumour has been classified as an osteoma, which originates from the body of the vertebrae. Osteoma is a benign, well-differentiated tumour with a structure that resembles bone tissue. It presents as a well-demarcated, hard, single tumour that can grow to a considerable size. The aetiology of osteomas in birds remains unclear because of the small number of cases described. Therefore, the influence of factors such as age, breed or sex, trauma, embryonic malformation, infection, developmental disorders, and genetic factors on the development of this type of tumour has not been established. Trauma seems to be the most obvious cause of growth in this case. This work provides valuable information about osteomas in birds, which is important for understanding such neoplasms.

