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The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats
Marko Gerić1, Lucia Nanić2, Vedran Micek3
1Division of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia.
Background:
Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate the potential geroprotective effects of resveratrol and melatonin in ageing rats.
Methods:
The animals were treated with these two compounds starting at 3 months of age and continuing until 1 year or 2 years of age. Using a multibiomarker approach, we assessed DNA damage, telomere length, and the oxidative status in their urine, liver, and kidneys.
Results:
Despite employing this experimental approach, our results did not provide conclusive evidence of geroprotective effects across the evaluated organs. However, we observed sex-dependent differences in response to treatment.
Conclusions:
Given the high potency of these two compounds, further research is warranted to explore their incorporation into daily routines as a strategy to mitigate ageing-related effects.
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