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The Development of a Coaxial Electrospinning Formula Using Fish Gelatin/PBS as the Core for Structurally Intact
Haoyu Wang1, Runnan Xia1, Mo Zhou1
1Division of Surgery & Interventional Science, University College London, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK.
Polymers
|April 12, 2025
Summary
This study developed a novel coaxial electrospinning method using fish gelatin to create rapid-release liposome-encapsulated fibers. This technique overcomes challenges in biocomponent stability for advanced drug delivery systems.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Coaxial electrospinning offers potential for biocomponent encapsulation and controlled release in scaffolds.
- Encapsulating sensitive biocomponents like liposomes is challenging due to solvent instability.
Purpose of the Study:
- To develop a novel coaxial electrospinning formulation for liposome-encapsulated, rapid-release coaxial fibers.
- To address the instability of liposomes in conventional electrospinning solvents.
Main Methods:
- Liposomes were stabilized in fish gelatin/phosphate-buffered saline (PBS) solutions.
- Coaxial fibers were fabricated using a fish gelatin/PBS core and a polycaprolactone (PCL)/chloroform/N,N-dimethylformamide (DMF) shell.
- Fluorescent labeling confirmed successful liposome encapsulation.
Main Results:
- Fish gelatin/PBS solutions exhibited good liposome stability and spinnability (>80% w/v).
- Successfully encapsulated liposomes within PCL coaxial fibers.
- Gelatin/PBS core formed solid ends, enabling rapid liposome release upon dissolution in medium.
Conclusions:
- A novel method for creating liposome-loaded electrospun coaxial fibers was successfully developed.
- The fish gelatin formulation enables rapid liposome release, showing potential for advanced delivery systems.
- This approach overcomes previous limitations in biocomponent encapsulation stability.
