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Is Insulin Resistance Present in Children With Subclinical Hypothyroidism?

Amine Aktar Karakaya1, Edip Unal1, Aslı Beştaş1

  • 1Department of Pediatric Endocrinology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.

Clinical Pediatrics
|April 12, 2025
PubMed

Insights

Subclinical hypothyroidism (SH) in children does not appear to affect insulin resistance or glucose metabolism. Further research is needed to understand the long-term metabolic and cardiovascular impacts of SH.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Thyroid Function

Background:

  • Limited research exists on subclinical hypothyroidism (SH) effects in pediatric glucose metabolism and insulin resistance.
  • SH is a condition where thyroid hormone levels are slightly abnormal, but symptoms may not be obvious.

Purpose of the Study:

  • To investigate the relationship between subclinical hypothyroidism and insulin resistance in children.
  • To compare glucose and insulin levels, as well as HOMA-IR, in children with and without SH.

Main Methods:

  • Compared 50 children diagnosed with SH against 50 healthy children.
  • Measured fasting blood glucose, insulin levels, and calculated HOMA-IR for all participants.
  • Analyzed correlations between thyroid-stimulating hormone (TSH) and free thyroxine (fT4) with metabolic parameters.

Main Results:

  • No statistically significant differences were observed in glucose, insulin, or HOMA-IR between children with SH and healthy controls.
  • No significant correlations were found between TSH/fT4 levels and glucose, insulin, or HOMA-IR in the SH group.
  • The study suggests SH does not induce insulin resistance in pediatric populations.

Conclusions:

  • Subclinical hypothyroidism in children does not appear to be associated with insulin resistance or altered glucose metabolism.
  • Potential for increased weight gain in children with SH warrants further investigation.
  • Long-term metabolic and cardiovascular consequences of pediatric SH require more extensive research.

Keywords:
HOMA-IRchildhoodglucoseinsulin resistancesubclinical hypothyroidism

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