Advancing nanocellulose-based biosensors: pioneering eco-friendly solutions for biomedical applications and...

The escalating demand for sustainable and high-performance biosensing technologies has intensified interest in nanocellulose-based biosensors as eco-friendly alternatives to conventional materials. Nanocellulose, derived from abundant natural sources, offers remarkable properties such as high surface area, mechanical strength, biocompatibility, and chemical versatility, making it highly suitable for biosensing applications. This review delves into the synthesis, functionalization, and diverse applications of nanocellulose materials, particularly bacterial nanocellulose (BNC) and cellulose nanofibrils (CNFs), in the development of advanced biosensors. Innovative functionalization techniques, including polymer grafting and TEMPO oxidation, have been employed to enhance the specificity, stability, and sensitivity of these biosensors. These advancements lay the foundation for a sustainable and efficient biosensing framework, positioning nanocellulose-based technologies at the forefront of developing eco-friendly and accessible biosensors for biomedical applications and beyond.