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Updated: Aug 6, 2026
10:37
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
Pathophysiological and Therapeutic Association between Brain-Gut Axis and Irritable Bowel Syndrome: A Systematic
Usman Farooq1, Ayesha Sadiqa2, Shaista Arshad Jarral3
1Usman Farooq, House Surgeon at Rashid Lateef Medical College, Lahore, Pakistan.
Pakistan Journal of Medical Sciences
|July 23, 2026
Summary
Irritable Bowel Syndrome (IBS) is linked to gut microbiota and brain function. Personalized management plans integrating diet, microbiome therapies, and psychological interventions are recommended for this complex condition.
Area of Science:
- Gastroenterology and Neuroscience
- Microbiome Research
- Personalized Medicine
Background:
- Irritable Bowel Syndrome (IBS) is a complex, multidimensional disorder.
- It involves gut hypersensitivity, immune dysregulation, gut flora imbalance, and psychological factors.
- Understanding the brain-gut axis is crucial for IBS management.
Purpose of the Study:
- To explore the association between the gut, brain, and microbiota in IBS.
- To identify optimal personalized management strategies for IBS.
- To align IBS care with personalized healthcare and evidence-based medicine.
Main Methods:
- A systematic review of studies from 2007-2025 was conducted.
- Databases included Scopus, MEDLINE, PubMed, Web of Science, ScienceDirect, Cochrane Library, Embase, and Google Scholar.
- PRISMA guidelines were used for data extraction from 49 manuscripts.
Main Results:
- IBS pathogenesis involves gut dysbiosis, hyper-immunity, visceral hypersensitivity, and stress-axis dysregulation.
- Conventional treatments include diet, antibiotics, and neuroregulators.
- Emerging therapies like Fecal Microbiota Transplantation (FMT) and psychedelic-assisted therapy show promise.
Conclusions:
- IBS is a multisystem pathology requiring a multimodal approach.
- Personalized management should integrate dietary, microbiome-targeted, pharmacological, and psychological therapies.
- Treatment should be tailored to individual symptomology and etiology.
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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