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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
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Relationship between physical activity and DNA methylation-predicted epigenetic clocks
Yanwei You1,2, Yuquan Chen3, Hao Ding1,2
1Division of Sports Science & Physical Education, Tsinghua University, Beijing, 100084, China.
Npj Aging
|April 12, 2025
Summary
Higher physical activity (PA) is linked to younger biological age, as measured by DNA methylation (DNAm) epigenetic clocks. This suggests PA can slow biological aging and reduce health risks.
Area of Science:
- Gerontology
- Molecular Biology
- Public Health
Background:
- Epigenetic clocks, such as DNA methylation (DNAm)-based measures, offer insights into biological aging.
- Physical activity (PA) is a known factor influencing health and longevity.
- Understanding the link between PA and epigenetic aging is crucial for developing interventions.
Purpose of the Study:
- To investigate the association between physical activity levels and DNA methylation-predicted epigenetic ages.
- To identify specific epigenetic clocks most affected by physical activity.
- To explore demographic and lifestyle factors that may modify this relationship.
Main Methods:
- Analysis of a U.S. population sample (n=948, mean age 62).
- Assessment of eight different DNA methylation-predicted epigenetic clocks.
- Multivariable linear regression models adjusted for covariates.
Main Results:
- Higher physical activity levels were significantly associated with younger epigenetic ages across all clocks.
- Strongest associations were observed for SkinBloodAge and LinAge.
- Associations were more pronounced in non-Hispanic whites, individuals with BMI 25-30, and former smokers.
Conclusions:
- Physical activity is a significant factor in slowing biological aging.
- PA may reduce biological age and associated health risks.
- Promoting PA is a viable strategy for healthy aging and disease prevention.
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