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The evolution of aging research: from theories to epigenetic reprogramming
Elena-Cristina Găitănaru1,2, Andreea Angelica Stroe1, Sergiu Emil Georgescu1
1University of Bucharest, Faculty of Biology, Splaiul Independentei 91-95, Bucharest, R-050095, Romania.
Npj Aging
|June 29, 2026
Summary
Aging results from multiple factors causing system degradation. Partial reprogramming using Yamanaka factors shows promise for extending lifespan and healthspan, with ongoing research addressing safety and efficacy for therapeutic use.
Area of Science:
- Gerontology and regenerative medicine.
- Cellular and molecular biology.
- Biomedical research.
Background:
- Aging is a complex process involving progressive degradation at molecular, cellular, and systemic levels.
- Multiple factors contribute to aging, impacting overall health and lifespan.
- Established anti-aging strategies exist, but partial reprogramming offers a novel therapeutic avenue.
Purpose of the Study:
- To review the historical context of aging theories.
- To evaluate the efficacy of established anti-aging interventions.
- To explore the potential of partial reprogramming for longevity and healthspan extension.
Main Methods:
- Historical review of aging research and theories.
- Analysis of existing anti-aging strategies.
- Examination of partial reprogramming techniques, including Yamanaka factors.
- Assessment of recent advancements and challenges in partial reprogramming.
Main Results:
- Aging is multifactorial, not attributable to a single cause.
- Partial reprogramming, utilizing Yamanaka factors, demonstrates potential for extending lifespan and healthspan.
- Recent progress has been made in enhancing the safety and efficacy of partial reprogramming.
Conclusions:
- Partial reprogramming is a promising anti-aging strategy with therapeutic potential.
- Overcoming current limitations in efficacy and safety is crucial for clinical application.
- Further research is needed to fully harness the benefits of partial reprogramming for human healthspan.
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